Literature summary extracted from

Baumann, R.P.; Shyam, K.; Penketh, P.G.; Remack, J.S.; Brent, T.P.; Sartorelli, A.C.
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity (2004), Cancer Chemother. Pharmacol., 53, 288-295.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.1.1.63	expression in CHO cells	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.63	methyl isocyanate	methyl isocyanate resulting from base-catalyzed activation of VNP40101M inhibits the enzyme, thereby enhancing the yield of the DNA G-C interstrand crosslink responsible for the antitumor activity of this agent	Homo sapiens
2.1.1.63	VNP40101M	methyl isocyanate resulting from base-catalyzed activation of VNP40101M inhibits the enzyme, thereby enhancing the yield of the DNA G-C interstrand crosslink responsible for the antitumor activity of this agent	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.63	Homo sapiens	-	-	-

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Release 2023.1 (January 2023)